We survey the literature on chronic progressive spastic paraparesis, with special emphasis on myelopathies, and propose a practical, MRI-based approach to facilitate the diagnostic process.

The hallmark of HSP is progressive difficulty walking due to increasingly weak and stiff (spastic) muscles. Symptoms appear in most people between the second and fourth decade of life, but they …

Four subjects in one family had childhood-to-adult onset progressive spastic paraparesis with intellectual impairment, dysarthria, seizures, pigmentary retinopathy, and visual impairment.

Hereditary spastic paraplegia (HSP) comprises a diverse group of neurodegenerative disorders characterized by progressive lower limb spasticity and weakness.

DISCUSSION of slowly progressive spastic paraparesis, MRI findings of thin corpus callosum and identification of pathogenic mutations in the SPG11 gene. Magnetic resonance imaging shows a thin …

Case Report PHYSICAL THERAPY INTERVENTIONS FOR THE PATIENTS WITH HEREDITARY SPASTIC PARA ESIS–AN EXPL

Certain spastic paraplegias, such as spastic paraplegia 7, may present as an ataxic phenotype and often share common pathophysiologic pathways with cerebellar ataxias.