Here, DeFronzo and colleagues explore the underappreciated adverse effects of insulin resistance and accompanying hyperinsulinaemia on the kidney, which is an insulin-responsive organ and has an ...

Scientific publishing relies on peer review as the mechanism that maintains trust in what we publish. When we read a journal article, we assume experts have rigorously scrutinised it before ...

This Review provides an integrated overview of Kupffer cell biology, from their embryonic origin and spatial organization to their functional specialization within the liver. It emphasizes how Kupffer ...